FEMS microbiology letters, 2017
Postdoctoral Research Associate
Department of Biochemistry and Molecular Biology
University of Georgia
Goff, J. L., & Yee, N. (2017). Tellurate enters Escherichia coli K-12 cells via the SulT-type sulfate transporter CysPUWA. FEMS Microbiology Letters.
Goff, Jennifer L, and N. Yee. “Tellurate Enters Escherichia Coli K-12 Cells via the SulT-Type Sulfate Transporter CysPUWA.” FEMS microbiology letters (2017).
Goff, Jennifer L., and N. Yee. “Tellurate Enters Escherichia Coli K-12 Cells via the SulT-Type Sulfate Transporter CysPUWA.” FEMS Microbiology Letters, 2017.
Soluble forms of tellurium are environmental contaminants that are toxic to microorganisms. While tellurite [Te(IV)] is a well-characterized antimicrobial agent, little is known about the interactions of tellurate [Te(VI)] with bacterial cells. In this study, we investigated the role of sulfate transporters in the uptake of tellurate in Escherichia coli K-12. Mutant strains carrying a deletion of the cysW gene in the CysPUWA sulfate transporter system accumulated less cellular tellurium and exhibited higher resistance to tellurate compared with the wild-type strain. Complementation of the mutation restored tellurate sensitivity and uptake. These results indicate that tellurate enters E. coli cells to cause toxic effects via the CysPUWA sulfate transporter.