APA
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Goff, J. L., Boyanov, M., Kemner, K., & Yee, N. (2021). The role of cysteine in tellurate reduction and toxicity. Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine.
Chicago/Turabian
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Goff, Jennifer L, M. Boyanov, K. Kemner, and N. Yee. “The Role of Cysteine in Tellurate Reduction and Toxicity.” Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2021).
MLA
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Goff, Jennifer L., et al. “The Role of Cysteine in Tellurate Reduction and Toxicity.” Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, 2021.
BibTeX Click to copy
@article{jennifer2021a,
title = {The role of cysteine in tellurate reduction and toxicity},
year = {2021},
journal = {Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine},
author = {Goff, Jennifer L and Boyanov, M. and Kemner, K. and Yee, N.}
}
The tellurium oxyanion tellurate is toxic to living organisms even at low concentrations; however, its mechanism of toxicity is poorly understood. Here, we show that exposure of Escherichia coli K-12 to tellurate results in reduction to elemental tellurium (Te[0]) and the formation of intracellular reactive oxygen species (ROS). Toxicity assays performed with E. coli indicated that pre-oxidation of the intracellular thiol pools increases cellular resistance to tellurate—suggesting that intracellular thiols are important in tellurate toxicity. X-ray absorption spectroscopy experiments demonstrated that cysteine reduces tellurate to elemental tellurium. This redox reaction was found to generate superoxide anions. These results indicate that tellurate reduction to Te(0) by cysteine is a source of ROS in the cytoplasm of tellurate-exposed cells.
