Jennifer L. Goff


Postdoctoral Research Associate


Curriculum vitae


JLGoff@uga.edu


Department of Biochemistry and Molecular Biology


University of Georgia



Extracellular sulfite is protective against reactive oxygen species and antibiotic stress in Shewanella oneidensis MR-1.


Journal article


Jennifer L Goff, J. Schaefer, N. Yee
Environmental microbiology reports, 2021

Semantic Scholar DOI PubMed
Cite

Cite

APA
Goff, J. L., Schaefer, J., & Yee, N. (2021). Extracellular sulfite is protective against reactive oxygen species and antibiotic stress in Shewanella oneidensis MR-1. Environmental Microbiology Reports.

Chicago/Turabian
Goff, Jennifer L, J. Schaefer, and N. Yee. “Extracellular Sulfite Is Protective against Reactive Oxygen Species and Antibiotic Stress in Shewanella Oneidensis MR-1.” Environmental microbiology reports (2021).

MLA
Goff, Jennifer L., et al. “Extracellular Sulfite Is Protective against Reactive Oxygen Species and Antibiotic Stress in Shewanella Oneidensis MR-1.” Environmental Microbiology Reports, 2021.


Abstract

In this study, we investigated the extracellular reactive sulfur species produced by Shewanella oneidensis MR-1 during growth. The results showed that sulfite is the major extracellular sulfur metabolite released to the growth medium under both aerobic and anaerobic growth conditions. Exogenous sulfite at physiological concentrations protected S. oneidensis MR-1 from hydrogen peroxide toxicity and enhanced tolerance to the beta-lactam antibiotics cefazolin, meropenem, doripenem and ertapenem. These findings suggest that the release of extracellular sulfite is a bacterial defence mechanism that plays a role in the mitigation of environmental stress.


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